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Tuesday, March 31, 2009

Detojet Hard Surface Cleaner

Question:
What cleaner would Alconox, Inc recommend for use in glass substrate and module in-process cleaning for large scale glass photovoltaic modules?

Answer:
Alconox, Inc. has introduced Detojet hard surface cleaner for use in glass substrate and module in-process cleaning for large scale glass photovoltaic modules. Detojet can be used in horizontal glass washers that clean the glass panels, followed by rinsing and drying prior to further processing.

Large glass superstrates of transparent conductive oxide coated glass can be cleaned prior to manufacturing and during manufacturing using large horizontal conveyor washers with Detojet cleaner. The combination of dispersants and cleaning agents results in excellent particle control and debris free surface. The dispersants are able to lift particles into solution by overcoming the electrostatic attractions to the hard surfaces and by reducing the hydrophobic tendency of the surface of the particle, thereby rendering it more water dispersible. The cleaning agents remove hydrophobic oily films that can interfere with the particle removing action of the dispersants as well as lead to non-uniform layers during manufacturing.

Detojet is available world wide thru a global network of dealers. See Alconox.com to find a local dealer.

For questions or an aqueous cleaner selection consultation contact the Experts in Critical Cleaning at Alconox, Inc. Email cleaning@alconox.com or call 914 948 4040 for technical support.

Thursday, March 26, 2009

Cleaning Thin Film Solar Modules

Question:
How does poor cleaning of thin film solar modules during manufacturing impact cost and yield?

Answer:
Poor cleaning of thin film solar modules can result in increased cost and reduced yield due to module faults from low electrical resistance between cells across laser scribe patterns; short circuits between cells in a module; and reduced steady state efficiency after extended light exposure to a module.

Substrates must be cleaned at the start of manufacturing AND after each significant residue creating process during manufacturing. Need help? Contact the Experts in Critical Cleaning at Alconox, Inc for an aqueous cleaner selection consultation. Email cleaning@alconox.com or call 914 948 4040 for technical support.

Tuesday, March 24, 2009

Rinse Water

Question:
How do you remove Alconox from rinse waters prior to discharge to the sewer? Will reverse osmosis work effectively in the removal of the Alconox from rinse waters?

Answer:
Alconox is a blend of organic surfactants and inorganic sodium salts of carbonates and phosphates. In principle, reverse osmosis will remove Alconox from water as long as you are using a sufficiently small molecular weight cut off to remove sodium carbonate. Although reverse osmosis would probably work, it might not be the most cost effective approach. Depending on why Alconox needs to be removed and if all of the components of Alconox need to be removed, there might be less expensive separation techniques that would work. To discuss further, please contact technical support at cleaning@alconox.com.

Thursday, March 19, 2009

The Aqueous Critical Cleaning Process

Question:
How does aqueous critical cleaning differ from basic cleaning for appearance? How does this apply to the pharmaceutical industry?

Answer:
The aqueous critical cleaning process involves using aqueous cleaners to remove residues from surfaces where the surface cannot function properly without successful cleaning. This is distinguished from simple cleaning for appearance. Aqueous critical cleaning is often used on high value surfaces or surfaces that are used to manufacture high value products. In the case of pharmaceutical manufacturing, the glass, ceramic, plastic, and metal surfaces that make up the tools and equipment used to manufacture pharmaceuticals must be free of any interfering cross contamination. If there is any interfering cross contamination, then the resulting high value pharmaceutical being made can be rendered unusable. There is also the risk that the cross contamination is not detected and contaminated pharmaceuticals can be released for use by humans or animals, thereby putting their health at risk, while exposing the manufacturer to liability. Surely, the aqueous cleaning processes in pharmaceutical manufacturing are some of the most critical of all aqueous critical cleaning processes.

Pharmaceutical process equipment, tools and R&D implements are typically made from fairly robust and cleanable materials such as stainless steel, Teflon, polypropylene, synthetic elastomers, glass and ceramic. Although the materials are relatively easy to clean, the tools and equipment often have difficult-to-clean structures. The kinds of residues found in pharmaceutical manufacturing can include many water-insoluble and otherwise very difficult-to-clean residues. Because of the broad range of formulations available with aqueous cleaners, it is possible to find a cleaner that will work even on the most difficult structures and residues by whatever cleaning method is desired. Not only can you find an effective cleaner, but aqueous cleaners are economical and are relatively safe for the environment and workers.

Learn more about aqueous critical cleaning from the experts who wrote The Aqueous Cleaning Handbook... Request your FREE hardcover copy - a $39.95 value - today by calling (914) 948 - 4040 or email request to cleaning@alconox.com, please include NAME and SHIP TO address.

Visit Alconox.com to learn more about Alconox, Inc aqueous brand cleaners for your high value pharmaceutical manufacturing equipment.

Tuesday, March 17, 2009

Benefits of Aqueous Critical Cleaning

Question:
What are the benefits of Aqueous Critical Cleaning in Pharmaceutical Manufacturing?

Answer:
The benefits of employing aqueous cleaning in pharmaceutical manufacturing are numerous. Virtually any pharmaceutical manufacturing equipment from tablet press to a stainless steel mixing tank can achieve their defined critically clean criteria using aqueous cleaning. Typically aqueous cleaners are formulated to ensure maximal cleaning performance by using key ingredients such as surface active agents (surfactants) that are excellent wetting agents that allow the cleaning solution to penetrate into crevices while getting under soils to allow for removal. Often very dilute solutions of aqueous cleaner effectively removes even worst case substances off a variety of hard surfaces including stainless steel, glass, plastic, or porcelain.

The proper use of aqueous cleaning helps manufacturers minimize surface residue and makes cleaning validation easier. Aqueous cleaners are available in low toxicity formulations that make achieving acceptable residue levels easy during cleaning validations. Often even multi-product facilities can find a single aqueous cleaner that cleans all residues on all surfaces. This means less cost for the manufacturer because only one cleaner has to be validated.

Aqueous cleaners are suitable for a variety of cleaning methods such as manual, soak, machine, and automated clean-in-place (CIP). The range in formulation from acidic to basic, high emulsifying to low foaming, and availability of liquid concentrates to powder blends ensures that a cleaner can be found to clean whatever residues are encountered using whatever the cleaning method is being used. Most pharmaceutical companies use liquids because they tend to be easier to handle when dispensing doses, though powders are more economical, especially for manual cleaning.

Aqueous cleaners are usually biodegradable, causing them to have low environmental impact, and are also readily disposable after use requiring no further treatment. Moreover, aqueous cleaners have excellent worker safety characteristics and replace semi aqueous or solvent-containing cleaners that tend to have more worker safety concerns and are harsher to the environment.

Learn more about aqueous critical cleaning from the experts who wrote The Aqueous Cleaning Handbook... Request your FREE hardcover copy - a $39.95 value - today by calling (914) 948 - 4040 or email request to cleaning@alconox.com, please include NAME and SHIP TO address.

Visit Alconox.com to learn more about Alconox, Inc aqueous brand cleaners for your high value pharmaceutical manufacturing equipment.

Thursday, March 12, 2009

How do I get the link for the new safety based limits and 10 ppm carryover limit calculator for Alconox brand cleaners?

Question:
How do I get the link for the new safety based limits and 10 ppm carryover limit calculator for Alconox brand cleaners?

Answer:
To request the online link for the residue calculator please call technical support at 914-948-4040 ext 151 or email cleaning@alconox.com or stop by Booth 3320 INTERPHEX2009 Pharmaceutical Manufacturing Conference and Exhibition at the Jacob Javits Center in New York City, NY March 17-19, 2009 and DEMO our brand NEW CALCULATOR for residue limits! It's a fast & simple tool especially created for the pharma engineer & validation specialist!

Thursday, March 05, 2009

NEW from Alconox – Calculator for Residue Acceptance Criteria Limits - For Alconox Inc. Detergents

Question:
How can the calculator help you? What pieces of information does this calculator require in order to perform calculation?

Answer:
As part of a cleaning validation, acceptable residue limits for the cleaner being used needs to be determined. This determination is made by calculating a safety based limit and comparing it to a 10 ppm carryover limit. The lower of these two limits calculated is the limit to adopt. In order to calculate the safety based acceptable residue limit, the acceptable daily intake (ADI) of the cleaner needs to be calculated. This requires several pieces of information including identification of the Alconox, Inc cleaner that is intended to be used as well as the typical weight of patients that will be exposed to the pharmaceuticals manufactured on the respective equipment being validated. An appropriate safety factor needs to be selected; usually the default is 1,000 unless it is a particularly hazardous material (1). The resulting ADI can then be used to calculate a safety based acceptance limit for cleaner residue by knowing the batch sizes to be manufactured, the surface area of the shared equipment being cleaned and largest daily patient dose of drug being manufactured. The result is the safety based limit. Next in order to calculate the 10 ppm carryover limit, you use the same batch size and equipment size used in the safety based limit to calculate the 10 ppm limit. The calculator automatically determines and displays the lower of the two limits calculated, either the safety based limit or the 10 ppm carryover limit. This is the residue acceptance criteria limit. The limit of quantitation for the analytical detection method you choose has to be below this limit so that the method is sensitive enough to detect at the residue acceptance limit.

To request the online link for the residue calculator please call technical support at 914-948-4040 ext 151 or email cleaning@alconox.com.

For product information, visit Alconox.com.

Tuesday, March 03, 2009

How to request Biocompatibility Data

Question:
What is the best way to request Liquinox or Citranox biocompatibility data?

Answer:
Teri Dowds
Director, Science & Marketing
Alconox Inc
914 948 4040 ext 151
tdowds@alconox.com
cleaning@alconox.com

At Alconox, we understand when you are cleaning Class III implantable medical devices, there's simply no margin for error!

Whether your product is designed for in vitro or in vivo use, is biomedical or electronic, there's an Alconox cleaner formulated to get products scrupulously clean without leaving interfering residues.

Powerful Alconox cleaners are available to remove particulates, bioburden, and interfering process oils from ceramic, plastic or stainless steel surfaces.

Full validation support including traceability, COAs, biocompatability, stability, reactivity and residue limits. Solutions for manual, ultrasonic, soak, clean-in-place applications, machine and pressure washers.

For more information on cleaning medical devices, visit our medical device cleaning page.

Thursday, February 26, 2009

Visit Alconox, Inc booth 3320 during PharmaMedDevice Symposium held concurrently with the INTERPHEX2009

Question:
Do the PharmaMedDevice Symposium conference attendees have access to the INTERPHEX exhibit floor? Is Alconox, Inc exhibiting at INTERPHEX2009?

Answer:
YES! Alconox, Inc will be attending the INTERPHEX2009 at the Jacob Javits Center in New York City, NY March 17-19, 2009. Stop by our booth 3320 for your free copy of The Aqueous Cleaning Handbook! Great opportunity to "Ask Alconox" and get experts advice about your medical device manufacturing cleaning needs!

In 2009, the PharmaMedDevice Symposium will once again run concurrently with the INTERPHEX Conference and Exhibition. Conference attendees will have access to the INTERPHEX exhibit floor showcasing the latest in products and ideas for the life science industry. Together, these educational programs provide Life Science professionals the knowledge and competitive advantage to accelerate product innovation.

For more information visit the PharmaMedDevice Symposium website.

Tuesday, February 24, 2009

Solujet Low-Foaming Phosphate-Free Liquid Detergent - Better Chemistry for Pharmaceutical Cleaning

Question:
What product will Alconox, Inc booth 3320 be highlighting at INTERPHEX2009?

Answer:
Solujet Low-Foaming Phosphate-Free Liquid Detergent

Alconox, Inc Booth 3320 INTERPHEX2009 offers superior cleaning with Solujet - even on your toughest pharmaceutical residues! With a superior surfactant system, Solujet out performs all others on the widest range of residues - even cleans titanium dioxide, tablet coatings and petrolatum - at low concentrations, without troublesome additives. Alconox, Inc adheres to cGMP and offers downloadable Certificates of Analysis, technical bulletins, MSDS and trace analysis directly from Alconox.com. For cleaning validation support including residue sampling techniques & analytical methods, visit us at Booth 3320.

Need to calculate Solujet or another Alconox brand cleaner residue acceptance limit for your manufacturing equipment? Stop by Booth 3320 and DEMO our brand NEW CALCULATOR for residue limits! It's a fast & simple tool especially created for the pharma engineer & validation specialist!

Solujet is concentrated to save money, distributed globally in convenient sizes up to 55 gal drums. For more information visit Alconox.com.

Thursday, February 19, 2009

Visit Alconox, Inc booth 3320 at INTERPHEX2009

Question:

Will Alconox, Inc attend the INTERPHEX2009 Pharmaceutical Manufacturing Conference and Exhibition?


Answer:

Alconox, Inc will be attending the INTERPHEX2009 Pharmaceutical Manufacturing Conference and Exhibition at the Jacob Javits Center in New York City, NY March 17-19, 2009. Stop by our booth 3320 for your free copy of The Aqueous Cleaning Handbook! Great opportunity to "Ask Alconox" and get experts advice about your industrial cleaning needs!

Mark your calendars for INTERPHEX2009 Pharmaceutical Manufacturing Conference and Exhibition!

INTERPHEX is the world's most trusted source for leading-edge technology, education, and sourcing of the products and services that drive scientific innovation for Life Sciences manufacturing from drug development to market - accelerating regulated products for patient care globally.

Thousands of Pharmaceutical Industry Professionals gather annually at INTERPHEX to meet one-on-one with technical experts, see the newest products and equipment, view live demonstrations, network, get expert advice to specific challenges, find resources and source new products, learn about emerging or changing trends, and to stay on top of every issue surrounding pharmaceutical manufacturing.

At INTERPHEX, you will find technology solutions and education for every aspect of drug manufacturing from process development through delivery to market. INTERPHEX is comprised of four major segments: Facilities, Outsourcing & Contract Services, Information Technology, and Manufacturing/Processing.

For more information on INTERPHEX2009, visit http://www.interphex.com/

Tuesday, February 17, 2009

Alconox, Inc targets toughest critical cleaning challenges

Question:
Why use Alconox brands? How do Alconox brands differ from the rest?

Answer:

Alconox brands are:

Fast acting, long lasting, high penetrating cleaners - powders, liquids, acids, alkalis, low-foaming and high emulsifying - biodegradable, phosphate-free and readily disposable

Expressly formulated to save time - high penetrating power for cleaning oxides, particles, flux & oil - FAST with LONG bath life

Formulated for your specific application - machine & parts washers, manual wash & ultrasonic tanks - concentrated to save $$

Corrosion inhibited formula - for glass, metal, ceramic and plastic

Precise quality control - COAs, MSDS, trace analysis & lab tests

Convenient sizes available worldwide: drums to bottles and boxes

For more information visit www.alconox.com

Thursday, February 12, 2009

Solujet Low-Foaming Phosphate-Free Liquid Detergent - Better Chemistry for Labware Washers!

Question:
What new cleaning chemistry will Alconox, Inc booth 4062 be featuring at Pittcon2009?

Answer:
Solujet Low-Foaming Phosphate-Free Liquid Detergent

Visit Alconox, Inc Booth 4062 to learn about Solujet and its unique formula for superior cleaning of glass, metal, plastic and ceramics in all kinds of machine washers- labware washers, dishwashers, washer sterilizers, washer-sanitizers, cart washers, and spray washers. Solujet is low-foaming, phosphate-free, biodegradable and readily disposable. Solujet saves time and cost due to rapid penetrating power and tackles the most demanding residues at low concentrations. With its free rinsing formula, Solujet leaves no interfering residues for reproducible results. Available in convenient sizes from a global network of laboratory & industry related suppliers. Solujet Certificate of Analysis, technical bulletin, MSDS, trace analysis and inhibitory residue tests are easily downloadable from Alconox.com.

Tuesday, February 10, 2009

Visit Alconox, Inc booth 4062 at Pittcon2009

Question:
Will Alconox, Inc attend the 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy - Pittcon - Show at the McCormick Conference Center Chicago, March 8-13, 2009?

Answer:
Alconox, Inc will be attending the 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy - Pittcon - Show in Chicago on March 8-13, 2009. Stop by our booth 4062 for your free copy the Labware Washer Guide designed to help you select the correct detergent. Great opportunity to "Ask Alconox" and get experts advice about your industrial cleaning needs!

Pittcon is the premier conference and exposition on laboratory sciences celebrates 60 years of service to the scientific community. Pittcon is the most comprehensive annual meeting on laboratory science in the world, offering a first class lab product exposition, a diverse, high quality technical program, unparalleled educational programs, and invaluable peer to peer networking opportunities. The 2009 venue is McCormick Place, Chicago, IL-a state of the art meeting facility in a vibrant, fun, and culturally rich city. Please visit often to learn more about Pittcon-the career building investment that you cannot afford to miss!
For more information on the 60th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy - Pittcon - visit http://www.pittcon.org/.

Tuesday, February 03, 2009

Alconox, Powdered Precision Cleaner BOD and COD

Question:
What are the BOD and COD for a 2% solution of Alconox?

Answer:
In a 2% Alconox solution, the results should be:
BOD = 540 mg/L
COD = 6800 mg/L

To view a technical bulletin for Alconox, please download our PDF.

Thursday, January 29, 2009

Cleaners for Cage Washers

Question:
What Alconox brand cleaners are best for use in cage washers?

Answer:
Alconox, Inc recommends a two step process that requires a first step alkaline cleaning using Solujet Low Foaming Phosphate Free Liquid, followed by an acid second step using Citrajet Low foaming Liquid Acid Cleaner/Rinse. The Solujet is used first to remove organic debris, feces and body fluids whereas the acid second step is used to remove urine scale and neutralize the cages. In some cases, Citrajet alone may be sufficient if the main concern is urine scale. In other cases, Solujet alone may be fine if the main concern is feces. This choice depends somewhat on the types of cages and animals being housed.

To read more about Solujet and Citrajet, visit Alconox.com.

Tuesday, January 27, 2009

Reduce BOD

Question:
Are there methods for reducing the BOD for wastewater effluent of DI + Alconox by removing organic compounds, i.e. surfactants?

Answer:
The surfactants are the major source of BOD in Alconox. A reverse osmosis membrane can remove the organic surfactants in Alconox. It is also possible to break down the surfactants using UV/oxidation with ozone or peroxide. The broken down surfactants will have reduced BOD. Also, adding an activated carbon filtration system after the oxidation step will further reduce the BOD level. It would also be possible to reduce the BOD using an activated carbon filtration system alone. It this case, a partition between water and activated carbon is created that favors the water, which means an oversized carbon filtration system, must be used to significantly reduce the surfactant content.

To view a technical bulletin for Alconox, visit download this PDF.

Friday, January 23, 2009

Assistance Selecting a Detergent

Question:
Does Alconox provide support to assist customers in selecting a detergent?

Answer:
Yes, ask the critical cleaning experts! We can assist you in detergent selection, answer general cleaning questions, arrange for a sample, and help with medical device and pharmaceutical cleaning validation for Alconox brand cleaners. Call us at 914.948.4040 or e-mail us at cleaning@alconox.com.

Visit our website www.alconox.com.

Tuesday, January 20, 2009

Low Foaming Detergent to clean silicon wafers

Question:
Does Alconox have a detergent to clean silicon wafers in a horizontal washer?

Answer:
Alconox, Inc. manufactures a very high purity product, Detergent 8, that is used in certain wafer cleaning and wafer tool cleaning processes. It is low foaming liquid that is typically used at 1-2% concentrations.

To learn more about Detergent 8, please download this informational PDF.

Tuesday, January 13, 2009

Cleaning Medical Devices

Question:
Are Alconox brand cleaners used widely in the medical device industry?

Answer:
Yes. Alconox brands are widely used in the medical device industry. Liquinox and Citranox are used to remove oils, grease, and mold release agents from recently machined medical devices. Whereas Tergazyme, an enzyme containing cleaner, is used to clean bodily fluids and blood off reusable medical devices after examinations and surgeries.

Whether cleaning manually, ultrasonically, or with automated cleaning systems, Alconox brand cleaners are formulated to remove residue and leave no interfering resides behind.

For more information on cleaning medical devices, visit our medical device section.