GHTF

Question:
What is the GHTF?

Answer:
Directly taken from www.GHTF.org, The Global Harmonization Task Force (GHTF) is a voluntary group of representatives from national medical device regulatory authorities and the regulated industry. Since its inception, the GHTF has been comprised of representatives from five founding members grouped into three geographical areas: Europe, Asia-Pacific and North America, each of which actively regulates medical devices using their own unique regulatory framework. The purpose of the GHTF is to encourage convergence in regulatory practices related to ensuring the safety, effectiveness, performance and quality of medical devices, as well as promoting technological innovation and facilitating international trade. The primary way in which this is accomplished is via the publication and dissemination of harmonized guidance documents on basic regulatory practices.

In this regard, Alconox aqueous cleaners are formulated to scrupulously clean medical devices to help manufacturer meet specified regulations, for more information please visit http://www.alconox.com/static/section_customer/ind_meddev.asp.

ICH

Question:
What is the objective of the ICH?

Answer:
According to www.ICH.org, The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the United States and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration.

The objective of ICH is to increase international harmonisation of technical requirements to ensure that safe, effective, and high quality medicines are developed and registered in the most efficient and cost-effective manner. These activities have been undertaken to promote public health, prevent unnecessary duplication of clinical trials in humans, and minimize the use of animal testing without compromising safety and effectiveness.

In this regard, keeping manufacturing equipment clean is necessary to avoid cross contamination. To ensure safety requirements are met and to maintain a high standard of quality for products, many pharmaceutical manufacturers use Alconox brand products for critical cleaning. Learn more about Alconox aqueous cleaners and validation support offered by Alconox critical cleaning experts! Visit www.alconox.com for more information.

Cleaning Validation Information

Question:
What is a definition of cleaning validation? Does Alconox provide cleaning validation support for Alconox brand cleaners?

Answer:
Cleaning Validation - Documented evidence with a high degree of certainty that a cleaning process will consistently produce product meeting its predetermined quality attributes. Quality attributes are typically those related to potentially contaminating residues.

Alconox, Inc provides validation support on all Alconox brand cleaners to assist in meeting cGMP guidelines. In fact, Alconox, Inc technical team has written The Aqueous Cleaning Handbook, and has dedicated chapters to Cleaning Validation (Chapter 8) and to Measuring Cleanliness (Chapter 10). For more information or get your free copy of The Aqueous Cleaning Handbook visit, http://www.alconox.com/section_customer/book_info.asp.

Calculating Cleaning Agent Safety Based Limits

Question:
Does Alconox provide information on calculating cleaning agent safety based limits?

Answer:
Alconox, Inc Pharmaceutical Cleaning Validation Method References has an entire section dedicated to cleaning agent safety based limits. Please visit here for more information: http://www.alconox.com/static/section_top/gen_cleanval.asp.

Cleaning agent safety based limits are typically calculated from a safety factor of an acceptable daily intake (ADI), a (1/1000 or more) reduction of an LD50 preferably by the same route of administration, or reproductive hazard levels. If the calculated limit is found to be higher than a less than 10 ppm carryover to the next batch, then the limit can be set to the more stringent 10 ppm carryover level for the safety based limit.

For additional information, the Alconox Technical Team has also written The Aqueous Cleaning Handbook, which in Chapter 10 discusses Measuring Cleanliness. For more information on the Handbook visit http://www.alconox.com/section_customer/book_info.asp.

Electronics Cleaning with no Hazardous Chemicals or Volatile Solvents

Question:
Why is it beneficial to use Detergent 8 when cleaning circuit boards and electronic components?

Answer:
Detergent 8 contains no conductive metal cations, and therefore it cannot leave conductive residues. Its coupling ability keeps soils suspended in the cleaning solution, not on the circuit boards. If the solution is promptly washed away with deionized water, boards will meet the omega-meter or ionograph standards of cleanliness. Detergent 8 can be used in a variety of electronic applications, such as, cleaning glass substrate before dichloric coating of electronic parts, cleaning during manufacturing and assembly, cleaning electronic contacts and leads as well as ceramic insulators and components.

Detergent 8 can be used manually, soak or spray. For more information please visit http://www.alconox.com/downloads/pdf/techbull_detergent8.pdf.

For more on cleaning electronics, please visit Alconox website at http://www.alconox.com/static/section_customer/ind_electronics.asp.

ar Reactor Cavity and Equipment Decontamination

Question:
What cleaner does Alconox recommend for the decontamination of nuclear reactor cavities and related equipment?

Answer:
Alconox recommends Detergent 8, a non-ionic, phosphate-free homogeneous blend of an alkanolamine, glycol ethers and an alkoxylated fatty alcohol for decontaminating nuclear reactors and related equipment including pipes, tools, and protective equipment. It contains no chelating agents or halides, or conductive metal cations. It is imperative to avoid detergents containing chelating agents as they can bond chemically to radioisotopes. Also it is important to avoid detergents containing fluorides, chlorides, or sulfur ingredients which might cause surface corrosion or intergranular stress corrosion of stainless components.

If the key concern is avoiding waste interference, then Detergent 8 is the brand to use. Detergent 8 can be used manually, soak or spray. For more information please click here.

Use Alconox brand products in the nuclear industry! Visit our website.

Alconox Brands for Ultrasonic Tank Cleaning

Question:
What is ultrasonic tank cleaning? Which industries commonly employ the method? What Alconox, Inc brands would be ideal for ultrasonic tank cleaning?

Answer:
Ultrasonic Tank cleaning works best on objects or part that are made of stainless steel, mild steel, aluminum, copper, brass, other alloys, plastic or rubber. The object to be cleaned is placed in a chamber containing a suitable ultrasound conducting fluid such as an aqueous cleaner depending on the application. Aqueous cleaners typically contain surfactants that reduce the surface tension of the water. An ultrasound generating transducer is built into the chamber, or may be lowered into the fluid. It is electronically activated to produce ultrasonic waves in the fluid. The main mechanism of cleaning action is by energy released from the creation and collapse of microscopic cavitation bubbles, which break up and lift off dirt and contaminants from the surface to be cleaned. The higher the frequency, the smaller the nodes between the cavitation points which allows for more precise cleaning.

Industrial ultrasonic cleaners are used in the automotive, printing, marine, medical instruments, medical device manufacturing, electroplating, and weapons industries.

Liquinox, critical cleaning liquid detergent, is a high emulsifying cleaner that is an excellent product for use in soak and ultrasonic cleaning. Citranox, acid cleaner and detergent, is also a high-emulsifying cleaner ideal for metal oxides and deposits.

Technical Bulletins and MSDS for each are downloadable from www.alconox.com or

• Liquinox Tech Bulletin: http://www.alconox.com/downloads/pdf/techbull_liquinox.pdf


• Liquinox MSDS: http://www.alconox.com/static/msds/msds_liquinox.asp


• Citranox Tech Bulletin: http://www.alconox.com/downloads/pdf/techbull_citranox.pdf


• Citranox MSDS: http://www.alconox.com/static/msds/msds_citranox.asp

Alconox Brands for Clean-In-Place (CIP) Systems

Question:
What Alconox brand cleaners are recommended for Clean-In-Place (CIP) systems? What information does Alconox offer to assist in validating CIP cleaners?

Answer:

It is desirable to use a low foaming cleaner that rinses freely in a CIP system. Selecting the appropriate CIP cleaner will be determined by the type of soil being removed as well as the hard surface being cleaned. Alconox, Inc manufacturers' several low foaming liquid cleaners that work well in CIP, including Solujet, an alkaline cleaner, and Citrajet, an acidic cleaner. An alkaline cleaner best removes oils, fats, grease and an acidic cleaner works best to remove insoluble hydroxides and metal oxides. Both Solujet and Citrajet are suitable to use on stainless steel manufacturing surfaces.

• Technical Bulletins and MSDS for each are downloadable from www.alconox.com
  
• Solujet Technical Bulletin: http://www.alconox.com/downloads/pdf/techbull_solujet.pdf
• Solujet MSDS: http://www.alconox.com/static/msds/msds_solujet.asp
• Citrajet Technical Bulletin: http://www.alconox.com/downloads/pdf/techbull_citrajet.pdf
• Citrajet MSDS: http://www.alconox.com/static/msds/msds_citrajet.asp

Alconox, Inc provides assistance to validate cleaners for CIP systems. Information on residue detection methods for Solujet and Citrajet can be found at http://www.alconox.com/static/section_top/gen_cleanval.asp.

Pharma Clean In Place (CIP) and Standard Operating Procedures (SOPs)

Question:
What is clean in place (CIP)? What are four reasons the pharmaceutical industry commonly employs clean in place (CIP) systems? Does Alconox, Inc have information on CIP Standard Operation Procedures (SOPs)?

Answer:
CIP stands for Clean-In-Place and is a method of cleaning the interior surfaces of closed systems and process equipment without dismantling the equipment. There are different types of CIP including, single pass systems and recirculation system.
The pharmaceutical industry heavily relies on clean in place (CIP) system because operators are not required to enter plant to clean, difficult to access areas can be cleaned, production time between production runs is minimized, and recycling the cleaner can reduce cost. Equipment used in pharmaceutical manufacturing must be cleaned before each use, and the cleaning procedure used must be in accordance with good manufacturing practices (GMPs). Alconox provides support to meet cGMP regulations. In fact, Alconox, Inc technical team has written The Aqueous Cleaning Handbook, where Standard Operating Procedures for CIP systems are discussed (see Chapter 7). For more information or get your free copy of The Aqueous Cleaning Handbook visit, http://www.alconox.com/section_customer/book_info.asp.

Alconox, Inc Provides Pharma Cleaning Validation Support

Question:
What is pharmaceutical cleaning validation? What information can Alconox, Inc provide to support pharmaceutical cleaning validation?

Answer:
Cleaning validation is the methodology used to assure that a cleaning process removes any residues of the active pharmaceutical ingredients (API) of the product manufactured, as well as any residual cleaning agent utilized in the cleaning process and any microbial contaminants on the surface of the manufacturing equipment or utensil. All residues are removed to predetermined levels to ensure the quality of the next product manufactured is not compromised by waste from the previous product.

Alconox, Inc provides validation support to help meet pharmaceutical cGMP requirements. Alconox, Inc Technical Team has written Pharmaceutical Cleaning Validation References that includes a directory of cleaner residue detection methods for each Alconox brand. Also to help comply with cGMP regulations all cleaner brands have traceable lot specific certificate of analysis (COA), Technical Bulletins and MSDS.

Alconox, Inc Support Pharma Manufacturers with CFR-Part 211.67

Question:
What is 21 CFR-Part 211.67? How can Alconox, Inc help pharmaceutical manufacturers meet these requirements?

Answer:
The Code of Federal Regulations (CFR) is a codification of the general and permanent rules published by the Government Printing Office (GPO) in the Federal Register (FR) by the Executive departments and agencies of the Federal Government. The FDA regulatory guidelines specifically for Title 21 CFR-Part 211.67 details the FDA clean standards on Equipment Cleaning and Maintenance. For more details visit, http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=211.67.

The Alconox technical support team has developed a guide for cleaning validation to help the pharmaceutical manufacturer meet these standards. The cleaning validation involves residue identification, residue detection method selection, sampling method selection, setting residue acceptance criteria, methods validation and recovery studies, and finally writing a procedure and training operators. This procedure is used to document acceptable residues three or more times and then establish a rational monitoring program that verifies that the validated state is being maintained. For more information please visit the Alconox website at www.alconox.com/static/section_top/gen_cleanval.asp.

MD&M East 2008, Alconox Booth #2266

Question:
Will Alconox, Inc attend the MD&M East Show in 2008?

Answer:
Alconox, Inc will be attending the MD&M East Show at the Jacob Javits Center New York City, NY on June 3-5. Stop by our booth #2266 for your free copy the Guide to Critical Cleaning or Aqueous Cleaning Handbook!

You'll want to visit Alconox, Inc booth #2266 at MD&M EAST because...

Alconox, Inc is The Leader in Critical Cleaning Detergents with sixty years of experience getting medical equipment critically clean for use in demanding human or veterinary health applications, and in the manufacturing of medical devices - such as titanium prosthetic hip joints - we understand how to clean to implantable standards. Whether the product is designed for in vitro or in vivo use, is biomechanical or electronic, you'll find an Alconox cleaner expressly formulated to get products scrupulously clean without leaving interfering residues.

You'll meet the Alconox, Inc technical experts who are ready to discuss your cleaning validation needs!

MD&M is the recognized resource since 1983 for everything you need to design and manufacture medical devices and equipment for today's increasingly competitive healthcare marketplace. For more information please visit this website: http://www.devicelink.com/expo/east07/.

Interphex2008, Alconox Booth #107

Question:
Will Alconox, Inc attend the INTERPHEX2008 Pharmaceutical Manufacturing Conference and Exhibition?

Answer:
Alconox, Inc will be attending the INTERPHEX2008 Pharmaceutical Manufacturing Conference and Exhibition at the Pennsylvania Convention Center - Philadelphia, PA March 26-28, 2008. Stop by our booth #107 for your free copy the Guide to Critical Cleaning or Aqueous Cleaning Handbook! Great opportunity to "Ask Alconox" and get experts advice about your industrial cleaning needs! Mark your calendars for INTERPHEX2008 Pharmaceutical Manufacturing Conference and Exhibition!

INTERPHEX is the world's most trusted source for leading-edge technology, education, and sourcing of the products and services that drive scientific innovation for Life Sciences manufacturing from drug development to market - accelerating regulated products for patient care globally.

INTERPHEX is the only Life Sciences event that represents a true cross-section of the pharmaceutical and biopharmaceutical industries. Industry-leading professionals worldwide make INTERPHEX the industry's annual focal point for driving change and efficiencies for the global pharmaceutical and biopharmaceutical market.
INTERPHEX will once again feature the co-location of PharmaMedDevice, the only comprehensive event to focus on the convergence of medical device, pharmaceutical, and biologic industries.

For more information about INTERPHEX, please click here.

Interphex Puerto Rico 2008, Alconox Booth #39

Question:
Will Alconox, Inc attend the INTERPHEX Puerto Rico 2008 Pharmaceutical Manufacturing Conference and Exhibition?

Answer:
Alconox, Inc will be attending the INTERPHEX Puerto Rico 2008 Pharmaceutical Manufacturing Conference and Exhibition at the Puerto Rico Convention Center, San Juan on February 14-15, 2008. Stop by our booth #39 for your free copy the Guide to Critical Cleaning or Aqueous Cleaning Handbook! Great opportunity to "Ask Alconox" and get expert advice about your industrial cleaning needs! Mark your calendars for INTERPHEX Puerto Rico 2008 Pharmaceutical Manufacturing Conference and Exhibition!

INTERPHEX Puerto Rico is the pharmaceutical industry's respected source of innovation, education, and professional advancement for a globally important center of drug manufacturing, from process development through delivery to market. Networking essential to business success is as important here as the exploration of new products and services that enhance human life and health.

For more information on INTERPHEX, please click here.

Sustainable, Safe, and Reduced Wasted Cleaning Processes

Question:
Is it possible in today's manufacturing environments to use safe, clean, reduced wasted cleaning processes that are ultimately sustainable?

Answer:
Yes it is possible in today's manufacturing environments to employ sustainable, safe, clean, and reduced wasted cleaning processes! The first step in evaluating the environmental health and safety of an aqueous cleaner is to secure the material safety data sheet and technical bulletins for the cleaners you plan to test or use, and to assemble as much information as you can about the soils you will be removing. A review of this information should disclose important environmental and health hazards as well as regulations.

When performing an initial review of regulations for an aqueous cleaner, it is important to consider Occupational Safety and Health Administration (OSHA) regulations, National Pollutant Discharge Elimination System (NPDES) discharge permits, Department of Environmental Protection (DEP) sewer connection/extension permits, and any Resource Conservation and Reclamation Act (RCRA) hazardous waste class or Clean Water Act regulations. State and local environmental regulations should also be considered.

It is wise to conduct a full scale environmental audit no matter what type of cleaning system you are using. Such an audit may result in changes in the way you currently manufacture and clean. In fact, after conducting a full-scale environmental audit many companies turn to aqueous cleaning achieve regulatory compliance easily and safely. A program of regular re-auditing can assure continued regulatory compliance.

Compared to hazardous nonaqueous and semiaqueous cleaners-particularly, those containing ozone-depleting fluorocarbon solvents, carcinogenic organic solvents, and/or flammable components-aqueous cleaners are good choices for safe, environmentally sound cleaning. By choosing high quality, environmentally sound aqueous cleaners, most cleaning problems can be solved without endangering workers or the environment.

Safety Issues in Aqueous Cleaning

Question:
What are the safety issues involved in aqueous cleaning?

Answer:
Worker safety issues, for aqueous cleaners, involve skin exposure, eye exposure, ingestion, inhalation, and chronic systemic exposure. Consult the label and material safety data sheet on the cleaner for warnings and safety precautions.

When cleaning by hand, it is always good practice to wear protective gloves. Even the mildest cleaners can sometimes cause "dishpan-hands". Gloves also provide protection and comfort when working, by hand, with hot solutions. In fact, many highly acidic or alkaline cleaners require the use of chemical-resistant gloves for worker safety. Eye exposure is also a concern with many aqueous cleaners.

Eye tissue is particularly vulnerable to attack by chemically active aqueous solutions. Accordingly, it is also considered good industrial practice to wear safety glasses or other eye protection when working with aqueous-cleaning solutions. Particularly hazardous aqueous cleaners should have warnings and recommended eye protection on the label.

In addition, there may be inhalation hazards with some aqueous cleaners. Because aqueous cleaners generally do not have volatile solvent ingredients, it is somewhat unusual to find the need for respiratory protection with such cleaners. However, it is considered good industrial practice to have some respiratory protection when working with sprays and mists in open-spray cleaning. Any special ventilation required should be noted on the material safety data sheet. Some semiaqueous cleaners may contain volatile solvents that require special ventilation and possibly even flammability controls.

While it is relatively unusual for an aqueous cleaner to contain any carcinogenic ingredients, the cleaner's material safety data sheet should disclose any long-term chronic exposure concerns relating to carcinogenicity.

Physical safety issues with aqueous cleaners, generally, concern storage and handling to avoid any hazardous reactions with other industrial chemicals. Good industrial practice usually involves storing acid and alkaline chemicals separately to avoid any reactions between them in the event of accidental spills. Some aqueous cleaners contain bleaches or other oxidizing agents that should be stored away from reactive chemicals that might undergo hazardous oxidation reactions. As previously mentioned, most completely aqueous cleaners are not flammable. However, some aqueous cleaners contain ingredients that form hazardous chemicals when burned. (It is considered good practice to wear respiratory protection when fighting any fire involving industrial chemicals.)

Cleaning Machined Plastic Implants

Question:
After machining plastic implants, what is the recommendation for an in process cleaning using a small ultrasonic tank?

Answer:
The recommendation would be to use 1% Liquinox (a mild alkaline, emulsifying and dispersing cleaner) at a temperature well within the temperature tolerance of the plastic. Warm solutions clean faster than ambient temperature ones, so if some heat is an option, use it. Liquinox would not harm plastics other than possibly stressed polycarbonate where there is potential for stress cracking. Stressed polycarbonate in the presence of heat and low surface tension solution (like a solvent or a detergent) will undergo stress cracking (fogging or crazing). Very dilute (0.25%) solutions of Liquinox used without heat can usually safely clean even stressed polycarbonate without problems - of course hopefully the polycarbonate is not that dirty because of course a 0.25% solution does not clean as well as the typical 1% solution.

Aqueous Cleaning and Environmental Issues

Question:
What are environmental issues are involved with aqueous cleaning?

Answer:
Generally, the environmental issues involved in aqueous cleaning have to do with the ingredients used and their ultimate discharge into the environment. Taking a larger view, it is also important to consider the energy and resources consumed in making and using the cleaner.

There are several important factors concerning discharge of spent cleaning solutions into the environment: biodegradability, aquatic toxicity and eutrophication acceleration. Early detergent formulations contained poorly biodegradable surfactants
that often caused foaming of lake and river surfaces after spent solutions were discharged to drain. All modern detergent formulations use biodegradable surfactants that do no buildup or persist in the environment causing foaming problems.

Aquatic toxicity can come from very high or very low pH or from toxic ingredients. Where extreme pH cleaning is required, it is advisable to neutralize or discharge spent solutions in small enough quantities to avoid problems. The surfactants in aqueous cleaners may be a source of aquatic toxicity. The use of biodegradable surfactants and the discharge of limited quantities of cleaning solutions generally results in safe concentrations of surfactants on water surfaces. Older, more highly toxic surfactants are rarely used in aqueous cleaner formulations.

Eutrophication involves cleaners that contain phosphates. Phosphorus is an essential nutrient for algae. When significant amounts of phosphorus are discharged into surface water, vigorous algae blooms may result. The algae die and settle to the bottom filling lakes and ponds with silt and organic matter more rapidly that normal. Although eutrophication is a normal, natural process, the acceleration of this process by phosphates is undesirable. The main source of phosphorous in surface waters is agricultural run-off from farming. There are no national regulations restricting the use of phosphates in cleaners, however, many states and municipalities have enacted legislation that restricts the use of phosphates in household cleaners. There are currently no restrictions on the use of phosphate containing cleaners in industrial cleaning applications.

Aqueous Cleaning Environmental Health and Safety Issues

Question:
What are the environmental health and safety issues that need to be considered when developing an aqueous cleaning process?

Answer:
Aqueous cleaners, by definition, use water for cleaning and rinsing. This has both advantages and disadvantages. Water is an inherently environmentally sound and substantially safe chemical to work with. It is a recyclable natural resource. Yet, as populations grow, clean surface water will become increasingly scarce. Water can also be a transport medium for various polluting or hazardous chemicals that may derive from the use of aqueous cleaning in specific instances.

One way to look at the environmental health and safety of a cleaning process is to consider:

• How hazardous is the cleaning process?
• How hazardous is the effluent resulting from the cleaning process?
• How sustainable-in terms of energy and resources-is the process?

All critical cleaning falls within a safety continuum. At one end are the polluting, hazardous processes; at the other, those that are to clean and safe processes; clean, safe, sustainable and produce little waste. Aqueous cleaning may fall anywhere along this continuum.

Of course, some aqueous cleaners do contain hazardous ingredients that may be used to clean hazardous soils, which may produce hazardous and polluting waste. But by the same token, industrial cleaning may involve the use of an aqueous cleaner with no hazardous ingredients used to clean the same hazardous soil, resulting in a clean and relatively safe process.

Improvement in safety can be achieved by eliminating the source of the hazardous soil in the process. Going a step further, waste can be reduced by integrating soil recycling, cleaning solution recycling and/or rinse water recycling into the cleaning process. It is possible to design a so-called "zero-discharge" system with no fluid effluent, limited volatile effluent and reduced solid waste by recycling cleaning and rinsing solutions using filters. In order to move toward a clean, safe and sustainable process, however, one would need to eliminate the hazardous soil and replace it with a non hazardous biodegradable soil. Then, after the water used in the cleaning and rinsing process has been recycled sufficiently, for energy efficiency, the now nonhazardous soil in the effluent would not pose no environment threat. Any water released could safely be incorporated into the natural water cycle (surface water evaporates to form clouds, which later precipitate as rain, and return as surface water).

It is, generally much more difficult to clean safely and sustainably using nonaqueous cleaning methods. Many nonaqueous cleaners are themselves health hazards, water pollutants, or air pollutants. Certainly not all nonaqueous cleaners are hazards and/or pollutants, but most lack a basic natural means, such as the water-cycle, of purifying and/or recycling key ingredients. Of course, this is an oversimplification. Given enough time, almost anything can complete a natural cycle of synthesis and decay. However, here, we are considering processes achievable in the course of a human lifetime.

One might argue that the carbon cycle, the nitrogen cycle, the oxygen cycle and other elemental cycles are involved in the decomposition and purification of ingredients used in nonaqueous cleaners. In fact, some of these cycles are also involved in the purification of ingredients found in aqueous cleaners but to a lesser degree. All of the cycles, noted above, involve multiple chemical transformations. They are slow processes in which chemicals may remain in one state for many years before degrading to a purer form. For example, during the nitrogen cycle, nitrogen remains in the air typically for years. Likewise, carbon takes the form of geological carbonates for extensive periods of time during the course of the carbon cycle, in some cases for millennia. Oxygen also remains tied up in the form of geological carbonates. These elements simply do not cycle rapidly, to a pure state, the way water does.

Cleaning Salicylic Acid

Question:
What can be used to manually clean lotions, creames, emulsions containing salicylic acid from manufacturing equipment?

Answer:
In general salicylic acid is best cleaned by sodium phosphate or alkali citrate salt containing cleaners. Creams and lotions are often best cleaned by high alkaline cleaners. Alconox powder is moderately alkaline sodium phosphate containing cleaner that is somewhat safer for manual use than some high alkaline cleaners. Alconox is a powder and some companies may much prefer a liquid. Alconox would work well here and would be better than Liquinox for this application. If the customer prefers a liquid, I would recommend either Detojet or Solujet. Note that Detojet and Solujet are both hazardous corrosive liquids that require skin and eye protection for handling. Solujet and Detojet must ship on non-passenger aircraft and can only be air shipped in the 5 gallon (19 L) size.